Publications

The crystal structure of Candida glabrata dihydrofolate reductase drives new inhibitor design toward efficacious antifungal agents

Jieying Liu, David B. Bolstad, Adrienne E. Smith, Nigel D. Priestley, Dennis L. Wright, Amy C. Anderson

Chem. Biol. 2008 15(9) 990–996

The crystal structure of Candida glabrata dihydrofolate reductase drives new inhibitor design toward efficacious antifungal agents Read More »

The alternating pattern of stereochemistry in the nonactin macrocycle is required for antibacterial activity and efficient ion binding

Publications / Promiliad Biopharma

Brian R. Kusche, Adrienne E. Smith, Michele A. McGuirl, Nigel D. Priestley

J. Am. Chem. Soc. 2009 131(47) 17155–17165

The alternating pattern of stereochemistry in the nonactin macrocycle is required for antibacterial activity and efficient ion binding Read More »

Natural Product Derivatives with Bactericidal Activity Against Gram-positive Pathogens Including Methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococcus faecalis

Publications / Promiliad Biopharma

Joshua B. Phillips, Adrienne E. Smith, Brian R. Kusche, Bradley A. Bessette, Jr, P. Whitney Swain, III, Stephen C. Bergmeier, Mark C. McMills, Dennis L. Wright, Nigel D. Priestley

Bioorg. Med. Chem. Lett. 2010 20(19) 5936–5938

Natural Product Derivatives with Bactericidal Activity Against Gram-positive Pathogens Including Methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococcus faecalis Read More »

Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes

Publications / Promiliad Biopharma

Kishore Viswanathan, Kathleen M. Frey, Eric W. Scocchera, Brooke D. Martin, P. Whitney Swain III, Jeremy B. Alverson, Nigel D. Priestley, Amy C.
Anderson, Dennis L. Wright

PLoS One 2012 7(2) e29434.

Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes Read More »

Crystal Structures of Klebsiella pneumoniae Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal Features for Potency and Selectivity

Publications / Promiliad Biopharma

Kristen M. Lamb, Michael N. Lombardo, Jeremy Alverson, Nigel D. Priestley, Dennis L. Wright, Amy C. Anderson

Antimicrob. Agents Chemother. 2014 58(12) 7484–7491

Crystal Structures of Klebsiella pneumoniae Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal Features for Potency and Selectivity Read More »

Pharmaceutical Analysis of a Novel Propargyl-linked Antifolate Antibiotic in the Mouse

Publications / Promiliad Biopharma

Brian R. Kusche, Adrienne E. Smith, Michele A. McGuirl, Nigel D. Priestley

J. Am. Chem. Soc. 2009 131(47) 17155–17165

Pharmaceutical Analysis of a Novel Propargyl-linked Antifolate Antibiotic in the Mouse Read More »

The crystal structure of Candida glabrata dihydrofolate reductase drives new inhibitor design toward efficacious antifungal agents

The alternating pattern of stereochemistry in the nonactin macrocycle is required for antibacterial activity and efficient ion binding

Natural Product Derivatives with Bactericidal Activity Against Gram-positive Pathogens Including Methicillin-resistant Staphylococcus aureus and Vancomycin-resistant Enterococcus faecalis

Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes

Crystal Structures of Klebsiella pneumoniae Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal Features for Potency and Selectivity

Pharmaceutical Analysis of a Novel Propargyl-linked Antifolate Antibiotic in the Mouse

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